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phenobarbital will lessen the level or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers may decrease partiaprevir and ritonavir levels, and so lessened efficacy of Viekira Pakphenobarbital will minimize the extent or outcome of lefamulin